For comparison, opioids, which include prescription pain relievers and heroin, killed more than 28,000 Americans in 2014. Nearly 88,000 people die from alcohol-related causes every year, which makes alcohol the fourth leading preventable cause of the death in the US.
It's pretty impossible to ingest a lethal dose of marijuana.
This is how much marijuana it would take to kill you — from @davidschmader's excellent book, "Weed." pic.twitter.com/ZM5qIjK1re— Melia Robinson (@meliarobin) November 4, 2016
David Schmader, author of "Weed: The User's Guide," spoke with experts and crunched the numbers on how much bud it would take to kill someone.
"Even aspirin can kill you if you take too much, but a fatal dose of marijuana would require ingestion of fifteen hundred pounds in fifteen minutes — a physical impossibility for any human, even Snoop Dogg," Schmader writes in his book.
One reason for this impossibility is the way the brain works. When a user ingests marijuana, chemicals in the plant ride the nervous system to the brain and latch onto molecules called cannabinoid receptors. Those little holding cells influence pleasure, memory, coordination, and cognition, among other functions, which is why getting high affects thinking and behavior.
Cannabinoid receptors are not found in the brainstem areas that control breathing. Thus, "lethal overdoses from cannabis and cannabinoids do not occur," The National Cancer Institute explains.
Marijuana isn't harmless, however. The psychoactive ingredient that gets users high, tetrahydrocannabinol, or THC, is a powerful intoxicant. Having physical abilities and judgments impaired can lead users to put themselves in unsafe situations.
And while there are no recorded cases of deaths from marijuana overdose, one bong rip too many can make users feel incredibly uncomfortable. Their heart starts to race, hands tremble, and anxiety strikes. There are things they can do to mitigate a "What I have done?" high.
In his book, Schmader recommends users tell themselves that they're in no real danger.
Drink some water to stay hydrated and eat a snack — preferably one that is ready-to-eat and does not require operating a stove — to boost your blood sugar. Call up a trusted friend, Schmader says, or Google search "Maureen Dowd Colorado" to feel less alone.